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Digital microfluidics: A promising technique for biochemical applications

He WANG, Liguo CHEN, Lining SUN

《机械工程前沿（英文）》 2017年 第12卷 第4期   页码 510-525 doi: 10.1007/s11465-017-0460-z

摘要：

Digital microfluidics (DMF) is a versatile microfluidics technology that has significant application potential in the areas of automation and miniaturization. In DMF, discrete droplets containing samples and reagents are controlled to implement a series of operations via electrowetting-on-dielectric. This process works by applying electrical potentials to an array of electrodes coated with a hydrophobic dielectric layer. Unlike microchannels, DMF facilitates precise control over multiple reaction processes without using complex pump, microvalve, and tubing networks. DMF also presents other distinct features, such as portability, less sample consumption, shorter chemical reaction time, flexibility, and easier combination with other technology types. Due to its unique advantages, DMF has been applied to a broad range of fields (e.g., chemistry, biology, medicine, and environment). This study reviews the basic principles of droplet actuation, configuration design, and fabrication of the DMF device, as well as discusses the latest progress in DMF from the biochemistry perspective.

关键词： digital microfluidics     electrowetting on dielectric     discrete droplet     biochemistry    

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A CFD study of the transport and fate of airborne droplets in a ventilated office: The role of droplet−droplet interactions

《环境科学与工程前沿（英文）》 2022年 第16卷 第3期 doi: 10.1007/s11783-021-1465-8

摘要：

• Coulomb and Lennard−Jones forces were considered for droplet interactions.

关键词： Droplet interactions     Aerosols     Colloids     CFD     Transport     Fate    

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Comparison of droplet distributions from fluidic and impact sprinklers

Xingye ZHU,Shouqi YUAN,Junping LIU,Xingfa LIU

《农业科学与工程前沿（英文）》 2015年 第2卷 第1期   页码 53-59 doi: 10.15302/J-FASE-2015049

摘要： To adapt to the trend toward low-energy precision irrigation, the droplet distributions for two new prototype sprinklers, outside signal sprinkler (OS) and fluidic sprinkler (FS), were compared with impact sprinkler (IS). A laser precipitation monitor was used to measure the droplet distributions. Droplet size and velocity distributions were tested under four operating pressures for nozzles 1.5 m above the ground. For the operating pressures tested, the mean OS, FS and IS droplet diameters ranged from 0 to 3.4, 0 to 3.5, 0 to 4.0 mm, respectively. The mean OS and FS droplet velocities ranged from 0 to 6.3 m·s , whereas IS ranged from 0 to 6.3 m·s . Being gas-liquid fluidic sprinklers, droplet distributions of the OS and FS were similar, although not identical. IS mostly produced a 0.5 mm larger droplet diameter and a 0.5 m·s greater velocity than OS and FS. A new empirical equation is proposed for determination of droplet size for OS and FS, which is sufficiently accurate and simple to use. Basic statistics for droplet size and velocity were performed on data obtained by the photographic methods. The mean droplet diameter (arithmetic, volumetric and median) decreased and the mean velocity increased in operating pressure for the three types of sprinkler.

关键词： outside signal sprinkler     fluidic sprinkler     impact sprinkler     sprinkler irrigation     droplet size     droplet velocity    

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Analysis of the radiation heat transfer process of phase change for a liquid droplet radiator in space

Jinying YIN, Linhua LIU

《能源前沿（英文）》 2011年 第5卷 第2期   页码 166-173 doi: 10.1007/s11708-010-0105-y

摘要： The optimization of a space power system is greatly affected by the radiation heat transfer in a liquid droplet radiator (LDR). Radiation heat transfer in a two-dimensional bed of phase-change particle is modeled by solving the radiative transfer equation using the discrete ordinates method and the energy equation using the implicit finite difference method. The Mie theory is used to calculate the radiative properties of the droplet bed, whereas the effective medium theory is used to obtain the optical constants of partial solidification droplets. Multiple factors affect heat flux in the LDR, such as size distribution, flow velocity, phase change of droplets, layer thickness, droplet concentration in the layer, and material type of the work fluid; each of these must be analyzed. Calculations show that once size distribution is neglected, the relative error increases significantly. Size distribution has a remarkably strong effect on heat flux when the flow velocity of the working fluid is above 100 m/s. An increase in flow velocity leads to an increase in the total heat flux for the layer with a fixed volume fraction of droplets. The solidification zone occupies nearly half of the layer, and droplets of different sizes exhibit temperature differences to some extent due to local thermal non-equilibrium among them. Droplet concentration in the layer and the material type of the working fluid have strong effects on heat flux, whereas the thickness of the layer has a mild influence on heat flux.

关键词： radiation heat transfer     particle polydispersion     liquid droplet radiator     phase change    

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Modeling and simulation of droplet translocation and fission by electrowetting-on-dielectrics (EWOD)

Nathan HOWELL, Weihua LI

《机械工程前沿（英文）》 2010年 第5卷 第4期   页码 376-388 doi: 10.1007/s11465-010-0104-z

摘要： This paper discusses methods of microfluidic droplet actuation by means of electrowetting-on-dielectrics (EWOD) and provides a technique for modeling and simulating a microfluidic device by using the computational fluid dynamics (CFD) program, Flow3D. Digital or droplet microfluidics implies the manipulation of droplets on a scale of nanoliters (10 L) to femtoliters (10 L), as opposed to continuous microfluidics that involve the control of continuous fluid within a channel. The two operations in focus here are droplet translocation (moving) and droplet fission (splitting), in which the pressures and velocities within the droplet are analyzed and compared to existing works, both theoretical and experimental. The variation in the pressure of the leading and trailing faces of a droplet indicates the variation in surface energy—an important parameter that explains how a droplet will move toward a region of higher electric potential. The higher voltage on one side of a droplet reduces surface energy, which leads to an induced pressure drop, thus resulting in fluid motion. Flow3D simulations are for both water and blood droplets at voltages between 50 V and 200 V, and the droplet size, surface properties (Teflon coated), and geometry of the system are kept constant for each operation. Some peculiarities of the simulation are brought to light, such as instabilities of the system to higher voltages and fluids with higher dielectric constants, as well as the creation of a tertiary droplet when the applied voltage causes a large enough force during fission. The force distribution across the droplet provides a general understanding of the electrowetting effect and more specifically allows for a comparison between the effects that different voltages have on the forces at the droplet surface. The droplet position and mean kinetic energy of the droplet are also investigated and compared to other works, proving the dynamics of a droplet motion found here.

关键词： electrowetting-on-dielectrics (EWOD)     electrowetting     microfluidics     droplet translocation     droplet fission     Flow3D     dielectric constant    

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Dynamical analysis of droplet impact spreading on solid substrate

Zhaomiao LIU, Huamin LIU, Xin LIU,

《机械工程前沿（英文）》 2010年 第5卷 第3期   页码 308-315 doi: 10.1007/s11465-010-0020-2

摘要： This paper investigates the impact spreading of a droplet on a solid substrate using numerical simulation on the basis of a volume-of-fluid (VOF) model. The process of droplet spreading is described, the analysis of low speed and high speed droplet spreading, and more than one droplet spreading simultaneously is performed. The pressure, velocity, and spreading factor during the droplet spreading are reported. According to the spreading factor’s evolvement, the process of droplet spreading can be classified into spreading phase and recoiling phase. The spreading factors are almost the same at the low speed droplet spreading; however, the pressures on the substrate are quite different and air entrainment may be found as the impact speeds in a certain range. The impact speed impacts on the spreading factors in high speed droplet spreading. The spreading factor obviously increases with increasing impact speed; however, splashing will appear in the status when the speed is high enough in the high speed droplet spreading. The distance between the neighbor droplets affects the film’s quality, and only the distance between the static diameter and the maximum diameter can ensure the film’s quality. The results could help in understanding the process of droplet spreading and provide advice on the operation of a spray coating process.

关键词： droplet     impact spreading     numerical simulation    

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Synthesis of crystals and particles by crystallization and polymerization in droplet-based microfluidic

Jingtao WANG, Jin ZHANG, Junjie HAN,

《化学科学与工程前沿（英文）》 2010年 第4卷 第1期   页码 26-36 doi: 10.1007/s11705-009-0292-4

摘要： The recent advances in crystallization and polymerization assisted by droplet-based microfluidics to synthesize micro-particles and micro-crystals are reviewed in this paper. Droplet-based microfluidic devices are powerful tools to execute some precise controls and operations on the flow inside microchannels by adjusting fluid dynamics parameters to produce monodisperse emulsions or multiple-emulsions of various materials. Major features of this technique are producing particles of monodispersity to control the shape of particles in a new level, and to generate droplets of diverse materials including aqueous solutions, gels and polymers. Numerous microfluidic devices have been employed to generate monodisperse droplets of range from nm to μm, such as T junctions, flow-focusing devices and co-flow or cross-flow capillaries. These discrete, independently controllable droplets are ideal microreactors to be manipulated in the channels to synthesize the nanocrystals, protein crystals, polymer particles and microcapsules. The generated monodisperse particles or crystals are to meet different technical demands in many fields, such as crystal engineering, encapsulation and drug delivery systems. Microfluidic devices are promising tools in the synthesis of micron polymer particles that have diverse applications such as the photonic materials, ion-exchange and chromatography columns, and field-responsive rheological fluids. Processes assisted by microfluidic devices are able to produce the polymer particles (including Janus particles) with precise control over their sizes, size distribution, morphology and compositions. The technology of microfluidics has also been employed to generate core-shell microcapsules and solid microgels with precise controlled sizes and inner structures. The chosen “smart” materials are sensitive to an external stimulus such as the change of the pH, electric field and temperature. These complex particles are also able to be functionalized by encapsulating nanoparticles of special functions and by attaching some special groups like targeting ligands. The nucleation kinetics of some crystals like KNO was investigated in different microfluidic devices. Because of the elimination of the interactions among crystallites in bulk systems, using independent droplets may help to measure the nucleation rate more accurately. In structural biology, the droplets produced in microfluidic devices provide ideal platforms for protein crystallization on the nanoliter scale. Therefore, they become one of the promising tools to screen the optimal conditions of protein crystallization.

关键词： core-shell     monodisperse     nucleation     Microfluidic     different technical    

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A “Sequential Design of Simulations” approach for exploiting and calibrating discrete element simulations

《化学科学与工程前沿（英文）》 2022年 第16卷 第6期   页码 874-885 doi: 10.1007/s11705-021-2131-1

摘要： The flow behaviours of cohesive particles in the ring shear test were simulated and examined using discrete element method guided by a design of experiments methodology. A full factorial design was used as a screening design to reveal the effects of material properties of partcles. An augmented design extending the screening design to a response surface design was constructed to establish the relations between macroscopic shear stresses and particle properties. It is found that the powder flow in the shear cell can be classified into four regimes. Shear stress is found to be sensitive to particle friction coefficient, surface energy and Young’s modulus. A considerable fluctuation of shear stress is observed in high friction and low cohesion regime. In high cohesion regime, Young’s modulus appears to have a more significant effect on the shear stress at the point of incipient flow than the shear stress during the pre-shear process. The predictions from response surface designs were validated and compared with shear stresses measured from the Schulze ring shear test. It is found that simulations and experiments showed excellent agreement under a variety of consolidation conditions, which verifies the advantages and feasibility of using the proposed “Sequential Design of Simulations” approach.

关键词： discrete element method     cohesive materials     parameter calibration     ring shear cell     design of experiments    

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Numerical study of droplet dynamics impinging onto steel plate covered with scale layer

Jan BOHá?EK, Ale? HORáK

《机械工程前沿（英文）》 2010年 第5卷 第4期   页码 389-398 doi: 10.1007/s11465-010-0108-8

摘要： The steel hot rolling process is inseparably connected to an oxide layer called “scale” at high temperatures. Hydraulic descaling of rolled material is a part of all rolling trains. Surface quality after descaling is fundamental for the final surface quality of a rolled product. The process itself is not theoretically well described; various different approaches have been used to clarify the descaling problem. This paper describes the dynamics of high-speed impact between the compressible water droplet and the steel scale layer. The phenomenon is known as water hammer effect. The purpose of this study is to numerically verify the fact that impact stress can be a significant factor during the descaling process. Considering a high droplet impact speed (100–300 ms ), inferential extremely short time interval (0.1–5 μs) peaks in impact pressure reaching 300 MPa can be found. Droplet dynamics was simulated with the help of LS-Dyna solver, whereas the stress analysis was performed in ANSYS interface. The extreme pressure peaks of very short duration in an impact area are a new phenomenon in the descaling theory.

关键词： hydraulic descaling     scale     rolling     water-hammer     descaling theory    

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Improving existing “reaching law” for better discrete control of seismically-excited building structures

Zhijun LI, Zichen DENG

《结构与土木工程前沿（英文）》 2009年 第3卷 第2期   页码 111-116 doi: 10.1007/s11709-009-0022-5

摘要： In this paper, a novel “composite reaching law” was explained in details: 1) the equation of discrete motion for a control system; 2) the design of discrete-time variable structure control. In addition, the model of a three-storey shear-type building structure was used to verify the effectiveness of the discrete variable structure control method. The results of numerical example analysis of the model show that the control law can effectively reduce the peak value of seismic response of the building structure and the chattering effect of the control system.

关键词： discrete-time variable structure control     composite reaching law     chattering effect     saturated control law    

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A dynamic model of mobile concrete pump boom based on discrete time transfer matrix method

Wu REN, Yunxin WU, Zhaowei ZHANG

《机械工程前沿（英文）》 2013年 第8卷 第4期   页码 360-366 doi: 10.1007/s11465-013-0280-8

摘要：

Mobile concrete pump boom is typical multi-body large-scale motion manipulator. Due to posture constantly change in working process, kinematic rule and dynamic characteristic are difficult to solve. A dynamics model of a mobile concrete pump boom is established based on discrete time transfer matrix method (DTTMM). The boom system is divided into sub-structure A and sub-structure B. Sub-structure A is composed by the 1st boom and hydraulic actuator as well as the support. And sub-structure B is consists of the other three booms and corresponding hydraulic actuators. In the model, the booms and links are regarded as rigid elements and the hydraulic cylinders are equivalent to spring-damper. The booms are driven by the controllable hydraulic actuators. The overall dynamic equation and transfer matrix of the model can be assembled by sub-structures A and B. To get a precise result, step size and integration parameters are studied then. Next the tip displacement is calculated and compared with the result of ADAMS software. The displacement and rotation angle curves of the proposed method fit well with the ADAMS model. Besides it is convenient in modeling and saves time. So it is suitable for mobile concrete pump boom real-time monitoring and dynamic analysis. All of these provide reference to boom optimize and engineering application of such mechanisms.

关键词： multi-body     mobile concrete pump boom     discrete time transfer matrix method (DTTMM)     kinematic     dynamic     tip displacement    

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Application of coupled multi-body dynamics–discrete element method for optimization of particle damper

Danhui DAN, Qianqing WANG, Jiongxin GONG

《结构与土木工程前沿（英文）》 2021年 第15卷 第1期   页码 244-252 doi: 10.1007/s11709-021-0696-x

摘要： With the application of the particle damping technology to cable vibration attenuation, the rootless cable damper overcomes the limit in installation height of existing dampers. Damping is achieved through energy dissipation by collisions and friction. In this paper, a coupled multi-body dynamics–discrete element method is proposed to simulate the damping of the damper–cable system under a harmonic excitation. The analyses are done by combining the discrete element method in EDEM and multi-body dynamics in ADAMS. The simulation results demonstrate the damping efficiency of rootless particle damper under different excitations and reveal the influence of the design parameters on its performance, including the filling ratio, particle size, coefficient of restitution, and coefficient of friction.

关键词： granular material     vibration control     discrete element method     particle damper     cable vibration    

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Effect of UAV prewetting application during the flowering period of cotton on pesticide droplet deposition

Weixiang YAO, Xianju WANG, Yubin LAN, Ji JIN

《农业科学与工程前沿（英文）》 2018年 第5卷 第4期   页码 455-461 doi: 10.15302/J-FASE-2018232

摘要：

Prewetting process can reduce the contact angle between the droplet and the leaf blade, so that the droplet can more easily wet and spread, thereby increasing the quantity of deposition. To improve the effectiveness of pesticides on cotton leaves, prewetting by single-rotor electric unmanned aerial vehicles (UAV) was studied, focusing on the effects of pesticide deposition on cotton leaves during the flowering period. Cotton leaves in 0°–30°, 30°–60°, 60°–90° leaf blade angle ranges (angle between the leaf blade and the horizontal plane) were examined. In the first experiment, four different prewetting volumes (0, 1.6, 3.2 and 4.8 L) were sprayed by a single-rotor electric UAV on four cotton plots (plots A to D) each with an area of 120 m , and then each area was sprayed with a 0.8% (w/v) ponceau 2R solution by another single-rotor electric UAV. The results revealed that with no prewetting, droplet deposition quantity decreased with increasing leaf blade inclination. After prewetting, the mean droplet deposition quantity on plots B, C and D increased by 39.8%, 9.7% and 24.9%, respectively. The prewetting rate of 1.6 L per 120 m had the most significant effect on improving the deposition of droplets. It was also found that the mean droplet deposition quantity in each leaf blade angle range increased after prewetting. For the leaf blade angle range 60° to 90°, this increase was the most pronounced, with 0.043, 0.062, 0.057 and 0.048 L·cm in plots A–D, respectively. Also, droplet deposition uniformity in the leaf blade angle range 60°–90° was better after prewetting. These results should provide a valuable reference for future research and practice to improve the effectiveness of pesticides applied to cotton by aerial applications.

关键词： aerial spray     cotton     deposition     flowering period     leaf angle     prewetting     UAV    

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Gained switching-based fuzzy sliding mode control for a discrete-time underactuated robotic system with

Hui LI, Ruiqin LI, Jianwei ZHANG

《机械工程前沿（英文）》 2021年 第16卷 第2期   页码 353-362 doi: 10.1007/s11465-020-0620-4

摘要： This study proposes a gained switching-based discrete-time sliding mode control method to address the chattering issue in disturbed discrete-time systems, which suffer from various unknown uncertainties. Through the new structure of the designed reaching law, the proposed method can effectively increase the convergence speed while guaranteeing chattering-free control. The performance of controlling underactuated robotic systems can be further improved by the adoption of fuzzy logic to perform adaptive online hyper-parameter tuning. In addition, an underactuated robotic system with uncertainties is studied to validate the effectiveness of the proposed reaching law. Results reveal the dynamic performance and robustness of the proposed reaching law in the studied system and prove the proposed method’s superiority over other state-of-the-art methods.

关键词： sliding-mode control     robot control     discrete-time uncertain systems     fuzzy logic    

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Discrete-event stochastic systems with correlated inputs: Modeling and performance evaluation

《工程管理前沿（英文）》 2022年 第9卷 第2期   页码 214-220 doi: 10.1007/s42524-022-0192-6

摘要： In the majority of the previous works on discrete-event stochastic systems, they have been assumed to have independent input processes. However, in many applications, these input processes can be highly correlated. Furthermore, the performance measures of the systems with correlated inputs can be significantly different from those with independent inputs. In this paper, we provide an overview on some commonly used methods for modeling correlated input processes, and we discuss the difficulties and possible future research topics in the study of discrete-event stochastic systems with correlated inputs.

关键词： discrete-event stochastic system     correlated input     performance evaluation    

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标题 作者 时间 类型 操作

Digital microfluidics: A promising technique for biochemical applications

He WANG, Liguo CHEN, Lining SUN

期刊论文

A CFD study of the transport and fate of airborne droplets in a ventilated office: The role of droplet−droplet interactions

期刊论文

Comparison of droplet distributions from fluidic and impact sprinklers

Xingye ZHU,Shouqi YUAN,Junping LIU,Xingfa LIU

期刊论文

Analysis of the radiation heat transfer process of phase change for a liquid droplet radiator in space

Jinying YIN, Linhua LIU

期刊论文

Modeling and simulation of droplet translocation and fission by electrowetting-on-dielectrics (EWOD)

Nathan HOWELL, Weihua LI

期刊论文

Dynamical analysis of droplet impact spreading on solid substrate

Zhaomiao LIU, Huamin LIU, Xin LIU,

期刊论文

Synthesis of crystals and particles by crystallization and polymerization in droplet-based microfluidic

Jingtao WANG, Jin ZHANG, Junjie HAN,

期刊论文

A “Sequential Design of Simulations” approach for exploiting and calibrating discrete element simulations

期刊论文

Numerical study of droplet dynamics impinging onto steel plate covered with scale layer

Jan BOHá?EK, Ale? HORáK

期刊论文

Improving existing “reaching law” for better discrete control of seismically-excited building structures

Zhijun LI, Zichen DENG

期刊论文

A dynamic model of mobile concrete pump boom based on discrete time transfer matrix method

Wu REN, Yunxin WU, Zhaowei ZHANG

期刊论文

Application of coupled multi-body dynamics–discrete element method for optimization of particle damper

Danhui DAN, Qianqing WANG, Jiongxin GONG

期刊论文

Effect of UAV prewetting application during the flowering period of cotton on pesticide droplet deposition

Weixiang YAO, Xianju WANG, Yubin LAN, Ji JIN

期刊论文

Gained switching-based fuzzy sliding mode control for a discrete-time underactuated robotic system with

Hui LI, Ruiqin LI, Jianwei ZHANG

期刊论文

Discrete-event stochastic systems with correlated inputs: Modeling and performance evaluation

期刊论文